Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination
Identifieur interne : 001996 ( Main/Exploration ); précédent : 001995; suivant : 001997Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination
Auteurs : Baziel Gm Van Engelen [Pays-Bas] ; Kevin D. Pavelko [États-Unis] ; Moses Rodriguez [États-Unis]Source :
- Multiple Sclerosis [ 1352-4585 ] ; 1997-04.
English descriptors
- Teeft :
- Albumin concentration, Animal model, Arch neurol, Autoantibody, Beneficial effect, Cerebrospinal fluid, Clinical improvement, Control group, Delta increase, Demyelinating, Demyelination, Experimental demyelination, Experimental models, Full remyelination, Immune, Immune model, Immune response, Immune system, Immunoglobulin, Ivig, Ivig administration, Ivig treatment, Lysolecithin model, Mayo clinic, Monoclonal antibody, Multiple sclerosis, Myelin, Myelin repair, Neurol, Normal mice, Normal polyclonal, Optic neuritis, Passive transfer, Pathogenic role, Physiological role, Polyclonal, Remyelination, Rodriguez, Sclerosis, Sodium channels, Spinal cord, Spontaneous remyelination, System remyelination, Tmev, Tmev model, Virus model.
Abstract
Studies in both humans and experimental animals indicate that there is potential for full remyelination following CNS demyelination, but the factors that control the degree of myelin repair are unknown. In the Theiler's virus model of demyelination CNS remyelination can be promoted either by global immunosuppression or by selective immunoglobulin therapy. In this paper we discuss whether immunoglobulin-mediated remyelination is a characteristic of immune-mediated demyelination, or whether immunoglobulin-mediated remyelination also occurs in the toxic-traumatic model of lysolecithin-induced demyelination. Our data support the hypothesis that even in a non-primary immune model of demyelination, manipulating the immune system can be beneficial in myelin repair.
Url:
DOI: 10.1177/135245859700300203
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000333
- to stream Istex, to step Curation: 000300
- to stream Istex, to step Checkpoint: 000414
- to stream Main, to step Merge: 001A11
- to stream Main, to step Curation: 001996
Le document en format XML
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Pavelko</name></author><author wicri:is="90%"><name sortKey="Rodriguez, Moses" sort="Rodriguez, Moses" uniqKey="Rodriguez M" first="Moses" last="Rodriguez">Moses Rodriguez</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D820B4F9C884EC54416F170F93E304A5D10AD254</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1177/135245859700300203</idno><idno type="url">https://api.istex.fr/ark:/67375/M70-3GCWK6L8-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000333</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000333</idno><idno type="wicri:Area/Istex/Curation">000300</idno><idno type="wicri:Area/Istex/Checkpoint">000414</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000414</idno><idno type="wicri:doubleKey">1352-4585:1997:Van Engelen B:enhancement:of:central</idno><idno type="wicri:Area/Main/Merge">001A11</idno><idno type="wicri:Area/Main/Curation">001996</idno><idno type="wicri:Area/Main/Exploration">001996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination</title><author wicri:is="90%"><name sortKey="Van Engelen, Baziel Gm" sort="Van Engelen, Baziel Gm" uniqKey="Van Engelen B" first="Baziel Gm" last="Van Engelen">Baziel Gm Van Engelen</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota, USA, Institute of Neurology, University Hospital Nijmegen</wicri:regionArea><wicri:noRegion>University Hospital Nijmegen</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Pavelko, Kevin D" sort="Pavelko, Kevin D" uniqKey="Pavelko K" first="Kevin D" last="Pavelko">Kevin D. Pavelko</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Rodriguez, Moses" sort="Rodriguez, Moses" uniqKey="Rodriguez M" first="Moses" last="Rodriguez">Moses Rodriguez</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Multiple Sclerosis</title><idno type="ISSN">1352-4585</idno><idno type="eISSN">1477-0970</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="1997-04">1997-04</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="76">76</biblScope><biblScope unit="page" to="79">79</biblScope></imprint><idno type="ISSN">1352-4585</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1352-4585</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albumin concentration</term><term>Animal model</term><term>Arch neurol</term><term>Autoantibody</term><term>Beneficial effect</term><term>Cerebrospinal fluid</term><term>Clinical improvement</term><term>Control group</term><term>Delta increase</term><term>Demyelinating</term><term>Demyelination</term><term>Experimental demyelination</term><term>Experimental models</term><term>Full remyelination</term><term>Immune</term><term>Immune model</term><term>Immune response</term><term>Immune system</term><term>Immunoglobulin</term><term>Ivig</term><term>Ivig administration</term><term>Ivig treatment</term><term>Lysolecithin model</term><term>Mayo clinic</term><term>Monoclonal antibody</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin repair</term><term>Neurol</term><term>Normal mice</term><term>Normal polyclonal</term><term>Optic neuritis</term><term>Passive transfer</term><term>Pathogenic role</term><term>Physiological role</term><term>Polyclonal</term><term>Remyelination</term><term>Rodriguez</term><term>Sclerosis</term><term>Sodium channels</term><term>Spinal cord</term><term>Spontaneous remyelination</term><term>System remyelination</term><term>Tmev</term><term>Tmev model</term><term>Virus model</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies in both humans and experimental animals indicate that there is potential for full remyelination following CNS demyelination, but the factors that control the degree of myelin repair are unknown. In the Theiler's virus model of demyelination CNS remyelination can be promoted either by global immunosuppression or by selective immunoglobulin therapy. In this paper we discuss whether immunoglobulin-mediated remyelination is a characteristic of immune-mediated demyelination, or whether immunoglobulin-mediated remyelination also occurs in the toxic-traumatic model of lysolecithin-induced demyelination. Our data support the hypothesis that even in a non-primary immune model of demyelination, manipulating the immune system can be beneficial in myelin repair.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Van Engelen, Baziel Gm" sort="Van Engelen, Baziel Gm" uniqKey="Van Engelen B" first="Baziel Gm" last="Van Engelen">Baziel Gm Van Engelen</name></noRegion></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Pavelko, Kevin D" sort="Pavelko, Kevin D" uniqKey="Pavelko K" first="Kevin D" last="Pavelko">Kevin D. Pavelko</name></region><name sortKey="Rodriguez, Moses" sort="Rodriguez, Moses" uniqKey="Rodriguez M" first="Moses" last="Rodriguez">Moses Rodriguez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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